CXCR7 has key functions in promoting breast and lung tumor development and progression.

Transcripts of CXCR7 were detected within tumor cells and tumor free lungs, mainly in alveolar macrophage.

High expression of CXCR7 combined with Alpha fetoprotein in hepatocellular carcinoma correlates with extra-hepatic metastasis to lung after hepatectomy.

TGFbeta1-CXCR7 axis may be a prognostic marker and may provide novel targets for combinational therapies to be used in the treatment of advanced lung cancer in the future

Increased expression of the chemokine receptor CXCR7 constitutes a mechanism of resistance to EGFR kinase inhibitors in patients with non-small cell lung cancer through reactivation of ERK signaling.

Study suggests that the activation of CXCR7 on tumour blood vessels by its ligands may facilitate the progression of colorectal carcinoma (CRC) within lung but not within liver.