Links to all GeneRIF Items | 5664 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 24858037 (PSEN2) | The loss of PS2 could have a critical role in lung tumor development through the upregulation of iPLA2 activity by reducing gamma-secretase. |
| 29109765 (PSEN2) | The present data suggest that PS2 mutations suppress lung tumor development by inhibiting the iPLA2 activity of PRDX6 via a gamma-secretase cleavage mechanism and may explain the inverse relationship between lung cancer and Alzheimer's disease incidence. |