Links to all GeneRIF Items | 5584 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 15705582 (PRKCI) | an NNK-activated physiological Bad kinase, can phosphorylate and inactivate BH3, enhancing survival of lung cancer cells |
| 15994303 (PRKCI) | Data demonstrate that protein kinase Ciota is a critical lung cancer gene that activates a Rac1-->Pak-->Mek1,2-->Erk1,2 signaling pathway required for transformed growth. |
| 18632643 (PRKCI) | Atypical protein kinase C iota expression has a role in aurothiomalate sensitivity in lung cancer cells |
| 20945390 (PRKCI) | PKCiota is required for the transformed phenotype of lung, pancreatic, ovarian, prostate, colon, and brain cancer cells. |
| 24318287 (PRKCI) | It regulates progression of lung adenocarcinoma. |
| 24525231 (PRKCI) | The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. |
| 24636699 (PRKCI) | PKCiota gene amplification is correlated with gender, subtype and distant metastasis in Chinese patients with non-small cell lung cancer. |
| 31378680 (PRKCI) | LSL-Kras(G12D);Trp53(fl/fl) (KP)-mediated lung adenocarcinomas can develop through both PKCiota-dependent and PKCiota-independent pathways. |
| 31623973 (PRKCI) | Oncogenic protein kinase Ciota signaling mechanisms in lung cancer: Implications for improved therapeutic strategies. |
| 31968252 (PRKCI) | Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in lung Squamous Cell Carcinoma. |
| 32350115 (PRKCI) | Protein kinase Ciota promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells. |