Las1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility. It may be a tumor suppressor.

Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors.

Whole-genome association analyis of lung tumor susceptibility refined the Pas1 locus to a region of less than 0.5 Mb containing two strong candidates, Kras2 and Casc1 (also known as Las1).

The differential degradation of Las1-A/J and Las-B6 produced from the 2 corresponding alleles, has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis.

Identification of mouse Casc1 (Las1) as a candidate for lung cancer susceptibility, and comparison of the protein to the rat and human orthologs.