MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma.

MIG-6 is a tumor-suppressor gene associated with lung cancer

MIG-6 gene is differentially regulated in lung cancer and melanoma and can be epigenetically silenced by inhibitors of methylation and histone deacetylation.

Mig-6 is a potential biomarker for evaluation of tumor prognosis of lung cancer.

Demonstrate that Mig-6 could reverse gefitinib resistance through inhibition of EGFR/ERK pathway in non-small cell lung cancer cell lines.

Low MIG6 expression is associated with lung cancer.

our data suggest that dormant cancer cells with a high MIG6 expression level might be one of the causes of EGFR-TKI resistance in EGFR mutant lung cancer cells.

Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma.