Links to all GeneRIF Items | 5366 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 19372561 (PMAIP1) | Increased Noxa expression Results in Increased Sensitivity to ABT-737 in small cell lung cancer. |
| 23014529 (PMAIP1) | Oncolytic viruses selectively induced expression of TRAIL and Noxa in prostate cancer cells, lung cancer cells, and breast cancer cells downstream of RIG-I and MAVS. |
| 24525728 (PMAIP1) | Noxa recruits MCL-1 from the cytosol to the mitochondria modulating ABT-737 sensitivity in small cell lung cancer. |
| 27591266 (PMAIP1) | By ubiquitylating and degrading NOXA through activating CRL5, UBE2F selectively promotes lung cancer cell survival and could, therefore, serve as a novel cancer target |
| 30255595 (PMAIP1) | Our data showed that Bmi1 is highly expressed in human non-small cell lung cancer (NSCLC) tissues and cell lines. Knockdown of Bmi1 significantly suppressed NSCLC cell proliferation and colony formation. Deguelin treatment attenuated the binding activity of Bmi1 to the Noxa promoter, thus resulting in Noxa transcription and apoptosis activation |