Links to all GeneRIF Items | 5329 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 12174885 (PLAUR) | circulating UPA is not up-regulated by the circulating P105 fraction of the HER-2/neu proto-oncogene: in vivo evidence from patients with advanced non-small cell lung cancer |
| 12704669 (PLAUR) | uPAR expression in lung cancer is regulated at a posttranscriptional level by uPA |
| 14507113 (PLAUR) | Significant increases in uPAR were found in pretreatment determinations of patients with advanced small-cell lung cancer or non-small-cell lung cancer. |
| 17327908 (PLAUR) | uPA and uPAR are involved in generation of drug-resistant small-cell lung cancer cell phenotype. uPAR-positive cells may define a functionally important population of cancer cells in SCLC. |
| 17548471 (PLAUR) | These observations demonstrate a novel regulatory role for p53 as a uPAR mRNA binding protein that down-regulates uPAR expression, destabilizes uPAR mRNA, and thereby contributes to the viability of human airway epithelial or lung carcinoma cells. |
| 17706320 (PLAUR) | High tumour cell C4.4A expression is associated with shorter survival for non-small cell lung cancer patients. |
| 18940913 (PLAUR) | uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells. |
| 20937265 (PLAUR) | role of single nucleotide polymorphism of uPA and uPAR in non-small cell lung cancer |
| 23030781 (PLAUR) | Multivariate survival analysis demonstrated that high levels of uPAR(I) were significantly associated with short overall survival in small cell lung cancer patients |
| 25120753 (PLAUR) | these data suggest that uPAR and CXCR4 co-expression predicts worse prognosis of small cell lung cancer patients |
| 26050228 (PLAUR) | data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including macrophages |
| 29961070 (PLAUR) | results demonstrated that PLAUR induces geftinib-resistance through EGFR/p-AKT/survivin signaling pathway in gefitinib-resistant human lung adenocarcinoma cells. PLAUR could be a novel therapeutic target for gefitinib-resistant NSCLC patients. |
| 30280780 (PLAUR) | The epigenetic regulation of uPAR by HDAC1 confirms its indirect role in regulating p38 MAPK as lung tumors progress. |