Links to all GeneRIF Items | 5315 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 12820320 (PKM) | With the fuzzy logic method and a tumor marker panel (including the new marker tumor M2-PK), a useful diagnostic tool for the detection of progression in lung cancer patients is available |
| 22052977 (PKM) | findings show, in lung cancer cells, increases in intracellular ROS caused inhibition of PKM2 through oxidation of Cys(358);regulatory properties of PKM2 may confer an additional advantage to cancer cells by allowing them to withstand oxidative stress |
| 25233397 (PKM) | High PKM2 levels were associated with low platinum sensitivity in metastatic non-small-cell lung cancer. |
| 25444918 (PKM) | High Pyruvate Kinase, M2-Type expression is associated with low radiosensitivity in non-small cell lung cancer. |
| 26140362 (PKM) | purine biosynthetic pathway enzymes PPAT and PAICS, as well as pyruvate kinase activity are increased in lung cancer |
| 28259998 (PKM) | Study shows that the enhanced expression of PKM2 in lung cancer cells is likely associated with the biological properties of cancer stem cells. |
| 28418088 (PKM) | It has been found that the adaptor protein receptor for activated PKC kinase (RACK1) formed a complex with FGFR1 and PKM2, and activated the FGFR1/PKM2 signaling. The study shows that RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells. |
| 28489603 (PKM) | High PKM2 expression is associated with lung adenocarcinoma. |
| 28641694 (PKM) | Overexpression of miR-133b inhibited the growth and proliferation of lung cancer stem cells by down regulating PKM2. |
| 28778925 (PKM) | Data suggest that PKM1 and PKM2, alternative splice variants that interact with each other, are expressed and localized differently in lung carcinoma cell lines; PKM1 or PKM2 knockdown (via RNA interference) differentially affects net pyruvate kinase activity, mitochondrial biogenesis, energy metabolism, ATP level, autophagy, and apoptosis/cell viability. |
| 30925904 (PKM) | PKM2 regulated PD-L1 expression and was associated with poor outcomes in lung adenocarcinoma patients. |
| 31106485 (PKM) | Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells. |
| 32049010 (PKM) | Secreted Pyruvate Kinase M2 Promotes lung cancer Metastasis through Activating the Integrin Beta1/FAK Signaling pathway. |
| 32308748 (PKM) | Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1alpha axis. |