these results demonstrated for the first time that SIRT6 suppressed non-small cell lung cancer cells proliferation via down-regulation of Twist1 expression

SIRT6 expression in NSCLC could be a useful prognostic marker and that SIRT6 might represent a novel target gene for predicting sensitivity of chemotherapy in lung adenocarcinoma.

SIRT6 is upregulated in non-small cell lung cancer; it may have a functional role in promoting migration and invasion through ERK1/2/MMP9 signaling

Taken together, these data demonstrated that astragaloside IV sensitized tumor cells to gefitinib via regulation of SIRT6, suggesting that astragaloside IV may serve as potential therapeutic approach for lung cance

Downregulation of SIRT6 expression may promote non-small cell lung cancer malignancy in the Chinese Han population.