expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm

FOXP3 overexpression with associated with non-small cell lung cancer.

The up-regulation of Tregs and the FoxP3 gene with aging may play an essential role in oncogenesis and development of lung tumors in an elderly population.

High FOXP3 expression is associated with non-small cell lung cancer.

CD4, IL-17and Foxp3 may be involved in the tumor suppression caused by host immune response, and are related with non-small cell lung cancer invasion and metastasis.

The current study demonstrated for the first time the association of the FoxP3 SNP with a risk of developing non small lung cancer in the Chinese Han population.

Density of tumor-infiltrating FOXP3+ T cells indicated the degree of response for induction chemoradiotherapy and prognosis in patients treated with trimodality therapy for locally advanced non-small cell lung cancer.

The expression of CK19 tended to be positively correlated with the expression of FOXP3. High expression of FOXP3 in regional lymph nodes was a significant unfavorable prognostic factor in patients with stage I non-small cell lung cancer.

FOXP3 was expressed in lung adenocarcinoma tissue and A549 cells. FOXP3 inhibition decreased cell proliferation, migration, and invasion as well as the secretion of inhibitory cytokines. It enhanced lung adenocarcinoma cell proliferation via upregulating the levels of the cell cycle G1/S checkpoint gene CCND1.

Data suggest that forkhead box P3 protein (Foxp3) represents an important target for non-small-cell lung cancer (NSCLC) anti-tumor immunotherapy.

Low-Foxp3/high-CD8+tumor infiltrating lymphocytes were associated with prolonged disease-free survival in stage I non-small cell lung carcinomas.

Circulating IgG antibodies to FOXP3 could not be used as a biomarker for early diagnosis of non-small cell lung carcinoma.

FOXP3 can act as a co-activator to facilitate the Wnt-b-catenin signaling pathway, inducing epithelial-mesenchymal transition and tumor growth and metastasis in non-small cell lung cancer.

Studied lymphocyte phenotype in resected lymph nodes of patients with lung cancer by analyzing levels of Foxp3 and CD8 by immunohistochemical staining.

Downregulated expression of FOXP3 by siRNA transfection significantly inhibited cell proliferation and enhanced chemosensitivity to cisplatin in A549 lung adenocarcinoma cells.

High FOXP3 expression is associated with non-small cell lung cancer metastasis.

Hippo pathway and tumoral FOXP3 expression correlate with tumor growth in squamous cell carcinoma of the lung.

Umbelliprenin induced production of IFN-gamma and TNF-alpha, and reduced IL-10, IL-4, Foxp3 and TGF-beta in a mouse model of lung cancer.