Parkin is a tumor suppressor gene whose inactivation may play an important role in non-small cell lung cancer tumorigenesis

parkin KO reduces the development of lung tumors via cell cycle arrest by blocking the degradation of p21

Studied the entire coding sequences of human PARK2 gene in gastric, colorectal, breast, lung and prostate carcinoma by single-strand conformation polymorphism (SSCP) and subsequent direct DNA sequencing.

A recurrent mutation, c.823C>T (p.Arg275Trp), in PARK2 is associated with familial lung cancer.

Human lung adenocarcinomas express different parkin isoforms, which might represent markers of malignancy and could be linked to specific biological functions

Findings suggest that PARK2 might have a tumor suppressor role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer.

knockdown of parkin inhibited lung cancer cell growth and resulted in increased cell cycle arrest at the sub G0/G1 phase in NSCLC cells

Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.