PAI-1 is induced by oncostatin M in lung tumor cells

a novel role for p53 as an mRNA-binding protein that regulates increased PAI-1 expression and stabilization of PAI-1 mRNA in human lung epithelial and carcinoma cells

This study found a statistically significant difference between the groups with respect to genotype distribution. Consequently, we can say that the PAI-1 gene 4G/5G polymorphism is associated with lung cancer in Turkey.

data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including macrophages

High PAI-1 expression is associated radioresistance and aggressiveness of non-small cell lung cancer.

Study identified that rs7242 GT/GG genotypes located in the 3'-UTR of PAI-1 were significantly associated with an increased risk of radiation pneumonitis in lung cancer patients treated with radiotherapy.

PAI-1 was identified as the target gene of miR-34a and activated the Stat3 signaling pathway to promote epithelial-mesenchymal transition in non-small cell lung cancer cells.

PAI-1 and TGF-beta1 promote non-small cell lung cancer tumor cells and tumor-associated macrophages and might be valuable targets for cancer immunosuppression.

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma.