Links to all GeneRIF Items | 50507 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 24714748 (NOX4) | WT-p53 is a potent suppressor of TGF-beta-induced Nox4 in p53-null lung epithelial cells. tumour-associated mutant p53 (R175H or R280K) caused enhanced Nox4 expression in both TGF-beta-dependent and TGF-beta-independent pathways. |
| 25504436 (NOX4) | Data show that NOX4/Akt and IL-6/STAT3 signalings can reciprocally and positively regulate each other, leading to enhanced non-small cell lung cancer (NSCLC) cell proliferation and survival. |
| 26986073 (NOX4) | miR-99a directly regulates the invasion and migration in lung adenocarcinoma by targeting NOX4. |
| 27989748 (NOX4) | The results reveal that NOX4 promotes glycolysis, contributing to non-small cell lung cancer cells growth, and supports glutaminolysis for oxidative resistance. |