Oncostatin M induces tissue-type plasminogen activator and plasminogen activator inhibitor-1 in lung tumor cells

our findings suggested that OSM suppresses SLUG expression and tumor metastasis of lung adenocarcinoma cells through inducing the inhibitory effect of the STAT1-dependent pathway and suppressing the activating effect of STAT3-dependent signaling

our findings suggest that OSM plays a crucial role in the early steps of metastatic breast cancer progression, resulting in increased circulating tumor cell (CTC) and lung metastases as well as reduced survival. Therefore, early therapeutic inhibition of OSM in patients with breast cancer may prevent breast cancer metastasis.

OSM promotes tumour growth, and does so through altering the local lung environment with accumulation of M2 macrophages.