Silencing mu opioid receptor expression inhibits Lewis lung carcinoma invasion and cell progression by 50%-80%.

Overexpression of mu-opioid receptor in human bronchoalveolar carcinoma cells increases primary tumor growth rates in nude mice by approximately 2.5-fold and lung metastasis by approximately 20-fold, compared with vector control cells.

possible direct effect of MOR on opioid and growth factor-signaling and consequent proliferation, migration and EMT transition during lung cancer progression

The rs1799971 and rs1323040 polymorphisms of the OPRM1 gene and rs2032582 and rs1128503 polymorphisms of the ABCB1 gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.