miR-361-3p and miR-625* might have a protective influence on the development of non-small cell lung cancer.

Study shows that miR-361 functions as a novel tumor suppressor in non-small cell lung cancer (NSCLC) and the anti-oncogenic activity may involve its inhibition of the target gene SH2B1.

miR-361-5p acts as a tumor suppressor in lung cancer through down-regulation of FOXM1.

miR-361 targets 3'UTR of YAP mRNA to depress the proliferation of lung cancer cells

Suppression of miR361 expression promotes the apoptosis and induces cell cycle arrest of nonsmall cell lung cancer (NSCLC) cell lines. Also, miR361 is predicted to bind to SMAD2 3'UTR. These observations suggest that the oncogenic role of miR361 in lung adenocarcinoma cells is at least partially due to the inhibition of its target gene, SMAD2.