altered expression of DDR1 may contribute to malignant progression of non-small cell lung carcinoma

gain-of-function mutations in DDR2 are important oncogenic events in squamous cell lung cancer.

mutations in the DDR2 gene were recently identified in squamous cell lung cancer through a sequencing screen of 201 genes with a potential role in human cancer (including the entire tyrosine kinome).

SHP-2 is a key signalling node downstream of the DDR2 receptor in lung cancer.

Loss of DDR2 suppresses tumor angiogenesis and tumor metastasis to the lung.

Promising therapeutic opportunities based on existing and novel targeted small molecule inhibitors against DDR2 may provide new strategies for treating lung squamous cell cancer patients.

Our results highlight potential RTK-driven adaptive-resistant mechanisms upon DDR2 targeting, and they suggest new, rationale cotargeting strategies for DDR2-mutant lung squamous cell cancer

Overexpression of DDR2 might contribute to tumor progression in lung SQCC. The overexpression of DDR2 could be potential molecular target of lung SQCC.

DDR2 mutations were observed in 4% of cases of lung squamous cell carcinoma of European descent; no clinical characteristics were significantly associated with DDR2 mutation

mutations of KRAS and DDR2 were found in large cell carcinoma (LCC) and squamous cell carcinoma (SCC) subtypes, respectively, whereas mutations of TP53 were seen in SCC and lung adenocarcinoma subtypes with higher frequencies and LCC subtype with lower frequency in Iranian patients.

Discoidin Domain Receptors, DDR1b and DDR2, Promote tumour Growth within Collagen but DDR1b Suppresses Experimental lung Metastasis in HT1080 Xenografts.

DDR2 mutation can drive lung cancer initiation in vivo and provide a novel mouse model for lung cancer therapeutics studies.

The authors show in mouse breast tumors that the action of the collagen receptor DDR2 in cancer-associated fibroblasts controls tumor stiffness by reorganizing collagen fibers specifically at the tumor-stromal boundary. These changes were associated with lung metastases.