Links to all GeneRIF Items | 4853 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 22006338 (NOTCH2) | study describes a spectrum of inactivating somatic mutations of Notch receptors in lung and skin cancers, indicating that Notch loss of function plays a prominent role in multiple variants of squamous cell carcinomas |
| 28666642 (NOTCH2) | Notch2 is important in Club cell differentiation in normal lungs and adenocarcinoma. Notch2 is regulated mutually with Notch1, and the balance of the expression of Notch receptors could determine the biological behaviours of lung cancer cells. |
| 28849037 (NOTCH2) | IRF4 is overexpressed in human non-small cell lung cancer and activates the Notch signaling pathway. |
| 25184679 (Notch2) | the cell of origin of K-Ras-induced tumors in the lung depends on levels of Sox2 expression affecting Notch signaling |