Hypoxia dramatically elevates NOTCH signaling (especially NOTCH-1) in lung tumor cell lines.

Notch1 signal activation can inhibit the proliferation and neuroendocrine marker expression in small cell lung cancer cells, and may behave as a tumor suppressor.

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.

Notch signaling pathway regulates small cell lung cancer cells through its inhibitory effect on hASH1 transcription via HES1.

Notch-1 signaling is involved in the upregulation of survivin expression in lung cancer cells, which is synergized by HIF-1alpha.

Introduction of small interfering RNA directed against Notch1 reduces epidermal growth factor receptor-induced mucin 5AC oligomeric mucus MUC5AC expression in a lung carcinoma cell line.

study describes a spectrum of inactivating somatic mutations of Notch receptors in lung and skin cancers, indicating that Notch loss of function plays a prominent role in multiple variants of squamous cell carcinomas

ADAM10 promotes non-small cell lung cancer cell migration and invasion via the activation of the Notch1 signaling pathway

Results suggest that the radiation-sensitive protein NOTCH1 can be up-regulated in lung tissue from uranium miners by level of exposure to pulmonary carcinogens.

The correlation between TRB3 and Notch 1 expression revealed that Notch 1 was downregulated by the knockdown of TRB3 in the lung adenocarcinoma cell lines.

inhibition of CK2alpha down-regulates Notch1 signalling and subsequently reduces a cancer stem-like cell population in human lung cancer cells

lung adenocarcinoma cells may enhance Notch1 activation as a protective mechanism in response to pterostilbene treatment.

Data suggest that Notch-1 might play a novel role in acquired resistance of non-small cell lung cancer to EGFR inhibitor gefitinib.

Results identify a new functional role for a Notch1-Sox9 signaling axis in lung ADC that may explain the correlation of Sox9 with tumor progression, higher tumor grade, and poor lung cancer survival.

Notch1 in the largely inactivated phenotype is inversely associated with clinical stage progression in non-small cell lung cancer

preliminary test using synthetic human NOTCH1 EGF modules showed significant inhibitory effects on the proliferation and adhesiveness of human breast cancer cell line MCF-7 and lung adenocarcinoma epithelial cell line A549

Upregulated expression of Notch1 is associated with reduced radiosensitivity of lung cancer.

HDAC6, a primarily cytoplasmic deacetylase, mediates TGF-beta1-induced EMT in human lung cancer cells via activation of Notch1.

NOTCH1 as a potential therapeutic target to block lung cancer dissemination.

High Notch1 expression, but not Numb expression, is associated with favorable prognosis in small cell lung cancer.

Notch1, along with HIF-1alpha and IGF-1R/Akt/ERK/S6K1 signaling pathways, promotes malignant progression stimulated by prolonged cadmium exposure in the lung adenocarcinoma model

Studied the correlation between histone acetylation and Notch1 expression in lung carcinoma; results show a significant correlation between the level of acetylation of histone H3 surrounding the promoter region of Notch1, and expression of Notch1 in human lung cancer cell lines.

The study might indicate that rs312599 in Notch1 may be a novel biomarker for small cell lung cancer risk in Chinese non-smoking females.

co-expression of C-X-C chemokine receptor 4 and Notch1 is associated with tumor progression and lymphovascular invasion and is an independent indicator of poor survival in lung adenocarcinoma. In lung adenocarcinoma patients with high C-X-C chemokine receptor 4 and Notch1 expression, simultaneous inhibition of both factors might be an effective treatment strategy.

We performed multiplex immunohistochemistry to check for achaete-scute homolog 1 and Notch homolog 1 expression in 139 pulmonary neuroendocrine tumor samples... we propose that ASCL1 expression is not controlled by NOTCH1 in 50% of pulmonary neuroendocrine tumors cases

Effect of Notch1 gene on proliferation and chemo sensitivity of lung cancer A549 cells was studied.

IRF4 is overexpressed in human non-small cell lung cancer and activates the Notch signaling pathway.

High Notch1 expression is associated with invasiveness and tumorigenicity of non-small cell lung cancer.

The current data indicated that elevated Notch1 induced higher IL-22 secretion by CD4(+) T cells in lung adenocarcinoma patients, and Notch-AhR-IL-22 axis took part in the pathogenesis of lung adenocarcinoma.

miR-582-5p suppresses Non-small cell lung cancer cell lines' growth and invasion via targeting oncoprotein NOTCH1.

Targeted deep sequencing from multiple sources demonstrates increased NOTCH1 alterations in lung cancer patient plasma.

MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer.

LncRNA FEZF1-AS1 promotes non-small lung cancer cell migration and invasion through the up-regulation of NOTCH1 by serving as a sponge of miR-34a.

IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway.

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53.

the cell of origin of K-Ras-induced tumors in the lung depends on levels of Sox2 expression affecting Notch signaling