higher level of expression is associated with death in non-small cell lung cancer

This study suggests that NF-kB2 genetic variations, rs7897947 and rs12769316 are involved in Non-Small Cell lung cancer susceptibility, in treatment response and in clinical outcome.

Using gene expression and patient information from The cancer Genome Atlas (TCGA) database, this study found that expression of p52-associated genes was increased in lung adenocarcinomas and correlated with reduced survival, even in early stage disease.

NFKB2 SNPs may be a possible marker of non-small cell lung carcinoma in Polish males.

The study investigated the impact of non-canonical NF-kappaB signaling on lung carcinogenesis. p52 over-expression led to increased tumor number and progression after injection of the carcinogen urethane in mice. Gene expression analysis of lungs from transgenic mice combined with in vitro studies suggested that p52 promotes proliferation of lung epithelial cells through regulation of cell cycle-associated genes.