NEDD9 is upregulated in lung adenocarcinoma, and overexpression of NEDD9 protein has been strongly correlated with staging and differentiation grade and tumor size in lung adenocarcinoma.

HEF1 may have a role in carcinogenesis of lung cancer; miRNA be a therapeutic target

Overexpression of NEDD9 promoted lung metastasis of an lung cancer cell line in transgenic mice.

In clinical specimens, elevated expression of NEDD9 was associated with malignant progression and metastasis.CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.

Data indicate that NEDD9 knockdown significantly inhibits migration, invasion and metastasis of lung cancer cells in vitro and in vivo.

Knockdown of the NEDD9 gene results in suppression of lung adenocarcinoma cell proliferation, migration, invasion and cell growth in vitro and in vivo

Increased NEDD9 expression is associated with metastatic endometrial and lung cancers.

MiR-125a-5p may serve as a therapeutic agent for lung adenocarcinoma through its major target, NEDD9.

miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer.

Inhibition of p62/SQSTM1 sensitizes small-cell lung cancer cells to cisplatin-induced cytotoxicity by targeting NEDD9 expression.