The NBS1-185Gln variant is related with p53 gene mutations in lung cancer patients

NBS1 could be important in the pathogenesis of lung cancer

Our results show that the genetic variation in XRCC1, XRCC3 and NBS1 influence lung cancer susceptibility among women, and that combinations of risk alleles in the two HR genes can enhance the effects.

The G/G genotype at NBS1 rs1805794 site and the Hap4-GC haplotype and Hap4/Hap2 di-haplotype from rs1805794 and rs2735383 were both associated with lung cancer.

findings suggest that NBS1 polymorphisms may be genetic biomarkers for non-small cell lung cancer prognosis especially progression-free survival with platinum-based chemotherapy in the Chinese population

This meta-analysis supports that there is an association between NBS1 Glu185Gln polymorphism and lung cancer risk.

The adjusted HR relating smoking to mortality in non-small cell lung cancer (NSCLC) was greater for cases with the GG genotype of NBS1 rs1061302 than for cases with AA/AG genotypes.

NSB1 Glu185Gln polymorphism is associated with treatment response in advanced non-small cell lung cancer.

The rs1805794G>C of NBS1 may be a functional genetic biomarker for lung cancer.[meta-analysis]

Co-expression of HIF-1a and NBS1 in primary tumors of patients with lung adenocarcinoma correlates with a worse prognosis

To our knowledge, this is the first report of NBN gene mutation in an individual with lung cancer in the Arab world

The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer

Gamma-irradiation enhanced tumor development in Nbn(+/-) mice, giving rise to a high frequency of epithelial tumors, mostly in the thyroid and lung, as well as lymphomas.