Non-glycosylated tandem repeats of MUC1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ECM) in vitro and have a potential role in metastasis.

Results suggest that the large MUC1 allele is associated with susceptibility to lung adenocarcinoma and poor prognosis.

A novel classification of MUC1 expression pattern (HP, LP, and D) was correlated with tumor differentiation and postoperative survival in NSCLC, especially in lung adenocarcinoma.

A 35-gene MUC1-induced tumorigenesis signature predicts significant decreases in both disease-free and overall survival in patients with breast (n=295) and lung (n=442) cancers.

The utility of the tumour markers carcinoembryonic antigen, cancer antigen 125, carbohydrate antigen 19-9, carbohydrate antigen 15-3, alpha-fetoprotein and human chorionic gonadotropin for the diagnosis solitary pulmonary nodules, was investigated.

the percentage of lung carcinoma patients remaining unclassifiable by TTF-1/TP63 was twice that of the five-antibody (TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6) test

constitutively activated STAT3 regulates expression of MUC1, which mediates lung cancer cell survival and metastasis in vitro and in vivo.

High serum KL-6 is associated with lung cancer.

Overexpression of MUC1 enhances proangiogenic activity of non-small-cell lung cancer cells through activation of Akt and extracellular signal-regulated kinase pathways.

Low MUC1 expression is associated with pulmonary metastatic tumors.

Depolarized MUC1 expression was significantly associated with poor outcome in patients with lung cancer.

Mucin expression was not predictive of overall survival benefit from adjuvant chemotherapy in non-small cell lung cancer patients.

MUC1 expression in macrophages has a role in cigarette smoke-induced lung cancer through a mechanism involving the nuclear receptor PPAR-gamma

These findings support a model in which targeting MUC1-C inhibits mutant KRAS signaling in Non-small cell lung cancer cells and thereby reverses the epithelial-mesenchymal transition phenotype and decreases self-renewal.

Results show that MUC1 trans-membrane C-terminal subunit induces LIN28B expression, downregulates let-7 signaling and thereby promotes epithelial-mesenchymal transition and stemness in non-small cell lung cancer cells.

MUC1 plays an important role in tumor-associated macrophage-induced lung cancer stem cell progression; pterostilbene may have therapeutic potential for modulating the unfavorable effects of TAMs in lung cancer progression

High Muc1 expression is associated with lung adenocarcinoma.

A previously unrecognized central role for MUC1-C in integrating PD-L1 activation with suppression of immune effectors and poor clinical outcome in non-small-cell lung cancer.

Findings provide evidence that rs4072037 MUC1 does not have a significant impact on the pathogenesis or prognosis of lung adenocarcinoma (ADC), whereas KL-6 serum levels, which might reflecting the molecular length of MUC1, are significantly associated with lung ADC.

MUC1 gene interference was done to A549 cells to show its role in sensitivity of lung cancer cells to TNFalpha and DEX. Results of our experiments indicate that MUC1 may regulate the influence of inflammatory mediators in effects of glucocorticoids (GCs), as a regulatory target to improve therapeutics.

Results identified MUC1 as a novel target of 14-3-3zeta in lung adenocarcinoma. Its high expression is associated with poor survival in lung adenocarcinoma patients.

we wanted to explore whether STAT3 can be related to lymph node micrometastasis of non-small cell lung cancer (NSCLC). To address this question, we evaluated the expression of MUC1 mRNA in the lymph node samples of NSCLC to determine micrometastasis. Then, we evaluated what role STAT3 overexpression plays in lymph node micrometastasis of NSCLC.

patients suffering lung, breast, ovarian cancers, nephrotic syndrome, type 2 diabetes, endometrial cancer, coronary heart disease, cervical cancer, uremia, and other 12 diseases plus healthy controls >65 years old had significantly (p<0.05, -Log10p>1.30) increased median serum CA153 levels compared to that of healthy controls.

Diagnostic value of CA-153 and CYFRA 21-1 in predicting intraocular metastasis in patients with metastatic lung cancer.

GalNAc-T3 and MUC1, a combined predictor of prognosis and recurrence in solitary pulmonary adenocarcinoma initially diagnosed as malignant solitary pulmonary nodule (

Downregulated Mucin 1 alleviates paclitaxel resistance in nonsmall cell lung cancer cells.