CBS, MTHFR, and SLC19a1 are involved in metabolism of folate and lung cancer risk in China

MTHFR variant cytosine677thymine is associated with a moderately increased risk of lung cancer.

The effect of MTHFR polymorphisms (C677T, A1298C) on the risk of lung cancer was undetectable.

findings are consistent with the hypothesis that folate play a role in lung and head/neck carcinogenesis, and show the need to incorporate data on folate intake when interpreting results of MTHFR polymorphisms in relation to cancer risk

MTHFR wild-type or heterozygous mutations are associated with non-small-cell lung cancer.

MTHFR C677T genotype, but not the A1298C, was differently distributed between the lung cancer and control groups.

a methylene-tetrahydrofolate reductase gene polymorphism has a role in non-small cell lung cancer

Comparing lung cancer patients with and without deep venous thrombosis, MTHFR A1298C gene polymorphism differed significantly (P=0.040).

Association between MTHFR C677T polymorphisms and the risk of lung cancer in a Korean population. The T allele was found to provide a weak protective association with lung squamous cell carcinoma.

The MTHFR C677T polymorphism was significantly associated with lung cancer risk.

MTHFR polymorphisms and low folate consumption is associated with high DNA adducts resulting in lung cancer.

No evidence of any associations of MTHFR A1298C polymorphism with lung cancer was found.

Methylenetetrahydrofolate reductase gene C677T polymorphism is associated with lung cancer

frequency of MTHFR 667TT genotype were 37.2 percent in lung cancer cases compared with 23.1 percent in controls; individuals with 667CC/CT genotype displayed reduced risk of lung cancer compared with those with TT genotype; C667T polymorphism may have a significant effect on occurrence of lung cancer in Henan province

MTHFR 677TT genotype might increase the susceptibility of lung cancer, especially in Asians.

Between the major MTHFR 677 CC genotype, as well as the MTHFR 677 C allele and CT gene is strong association with lung cancer. expression

Combined germline variations in PAI-1 and MTHFR C677T genes were associated with genesis of lung cancer.

Methylenetetrahydrofolate reductase polymorphisms are associated with response to chemptherapy in non-small cell lung cancer.

MTHFRC677T polymorphism is not associated with lung cancer.

MTHFR C677T polymorphism is significantly associated with lung cancer in Asians.

This meta-analysis provides evidence that MTHFR C677T polymorphism may contribute to lung cancer development in North China.

Genetic polymorphism of MTHFR is associated with lung cancer.

Meta-analysis showed that the MTHFR C677T polymorphism is associated with a significant increase in lung cancer risk in Asian and overall populations, but not in Caucasian populations. No. significant association between the MTHFR A1298C polymorphism and lung cancer risk was found.

compared with wild-type genotype CC, patients with CT/TT genotypes had higher incidence of leukopenia, neutropenia, nausea, and fatigue among the non-squamous Non-Small Cell lung cancer patients. Therefore, MTHFR C677T polymorphism could be a predictive factor for leukopenia, neutropenia, nausea, and fatigue in non-squamous Non-Small Cell lung cancer patients receiving single-agent PEM treatment

Meta-analysis found that the CMTHFR C677T polymorphism was associated with a high risk of lung cancer in the overall Chinese and North Chinese populations. Study found that the T allele and TT genotype lead to an increased risk of lung cancer in Chinese people, but did not observe an association between the MTHFR A1298C polymorphism and lung cancer susceptibility.