High miR-370 expression is associated with aggressive lung adenocarcinoma.

Results show that miR-370 expression is downregulated in non-small cell lung cancer (NSCLC), its overexpression inhibits tumor formation in vivo and targets TRAF4 suggesting it as an important player in NSCLC pathogenesis through TRAF4 regulation.

Overexpression of these two microRNAs in A549 induced cell-cycle arrest and cell senescence, delayed cell proliferation and colony formation, and inhibited migration and invasion. In conclusion, microRNA-mediated RNAa depends on the cell context, and miR-1236 and miR-370 can inhibit non-small-cell lung carcinoma cell growth by upregulating p21 expression in vitro

Long noncoding RNA FAM201A involves in radioresistance of non-small-cell lung cancer by enhancing EGFR expression via miR-370.