this study validated the functions of the rs2239680 SNP in the mir-355-related regulation of BIRC5 in Chinese Han with lung cancer.

Upregulation of miR-335 can simultaneously suppress the invasiveness and promote apoptosis of lung cancer cell A549 and H1299 by targeting Bcl-w and SP1.

loss of miR-335 promoted Small cell lung cancer metastatic skeletal lesions via deregulation of IGF-IR and RANKL pathways and was associated with metastatic osteolytic skeletal lesions.

Data reported evidence that the SNPs rs76322625 and rs41281081 in the MET 3'UTR are involved in the occurrence of non-small-cell lung cancer. They are respectively regulated by miR-335 and miR-1026 causing up-regulation of MET in patients.

Overexpression of miR-335 decreased the expression of PARP-1 mRNA and protein, and NF-kappaB protein levels were correspondingly downregulated, thus regulating the chemo-radiosensitivity of small cell lung cancer cells.

Findings demonstrate that miR-335 is downregulated in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. Furthermore, miR-335 seems to target Tra2b. These results indicate that the interaction between miR-335 and Tra2b may play a vital role in the pathogenesis of NSCLC.

Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration.

Correlation of microRNA-335 expression level with clinical significance and prognosis in non-small cell lung cancer.