Overexpression of MMP-7 is associated with non-small cell lung cancer

Significantly higher expression of MMP-7 and MMP-9 in tumor tissue than in the surrounding tissue or in benign lung disease tissue supports the notion of an important role of these metalloproteinases in the growth of lung carcinoma

SNPs in MMP1, MMP2, MMP7 and MMP12 have roles in response to chemotherapy in lung cancer

fibulin-3 negatively modulates the invasiveness of lung cancer cells via regulation of MMP-7 and MMP-2 and its expression is regulated by hypermethylation of the promoter region

Antisense oligonucleotide targeting matrix metalloproteinase-7 (MMP-7) changes the ultrastructure of human A549 lung adenocarcinoma cells, inhibiting proliferation and invasion.

Data indicate that the plasma protein levels of MMP-7 in lung cancer patients were significantly higher than those in healthy control subjects.

Our meta-analysis results revealed that MMP-7 overexpression is associated with advanced TNM and histological grades, and is linked to aggressive LN metastasis in lung cancer patients.

EFEMP1 suppresses growth and invasion of lung cancer cells by downregulating MMP7 expression.

Data showed that AEG1 and MMP7 levels were both significantly increased and strongly correlated in non-small cell lung cancer (NSCLC) tissues. AEG-1 promotes NSCLC cell invasiveness through MAPK-p42/p44-dependent activation of MMP7.

Absence of MMP-7 Promoter Polymorphisms is associated with lung cancer Susceptibility.

MMP7 expression is regulated by Hes3 in lung cancer cells.