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Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

4314

PubMed (Gene Name)

Literature evidence

16311244 (MMP3)

matrix metalloproteinase 1, 3 and 12 haplotypes may associated with development of lung cancer, particularly among never smokers and men

22587600 (MMP3)

study may form an additional evidence for the association of MMP3 enzyme and genetic susceptibility to lung cancer

22786680 (MMP3)

Activation of epithelial-mesenchymal transition by MMP-induced expression of Rac1b gave rise to lung adenocarcinoma.

23744166 (MMP3)

Analysis of gene polymorphisms of proteolytic enzymes and inhibitors of the enzyme gene showed statistically significant differences between patients with COPD and lung cancer only for the MMP3 gene 6A/5A.

25292126 (MMP3)

Homozygocity for MMP3 rs3025058 and rs678815 polymorphisms is a potential marker of enhanced susceptibility to lung cancer development among COPD subjects.

29761931 (Mmp3)

Targeted knockdown of MMP3 attenuates proliferation, migration, and invasion of the metastatic adenocarcinoma cells. Nuclear PEX domain/MMP3 localized in primary tumor-stroma marginal area and lung-metastatic tumor nodules.