miR-99a/mTOR pathway was involved in diaporine A-induced tumor suppression in non-small cell lung cancer cells.

miR-99a directly regulates the invasion and migration in lung adenocarcinoma by targeting NOX4.

miR-99a reveals two novel targets E2F2 and EMR2 that play a key role in lung tumourigenesis. By inhibiting E2F2 and EMR2, miR-99a represses in vivo the transition of epithelial cells through an EMT process concomitantly with the inhibition of stemness features and consequently decreasing the CSC population.

Studies suggest that the protein arginine N-methyltransferase 5 (PRMT5)/miR-99 family/fibroblast growth factor receptor 3 (FGFR3) axis in regulating lung cancer progression and identifies PRMT5 as a promising prognostic biomarker and therapeutic target.