BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification.

The results demonstrate that miR-30a influences non-small cell lung cancer progression through PI3K/AKT signaling pathway by targeting IGF1R in A549 cells.

Validation of significant miRNAs in independent 40 paired NSCLC tissues demonstrated that the expression level of miR-486-5p and miR-30a-5p was significantly downregulated in another 40 paired lung cancer tissues

MiR-30a expression was significantly down-regulated in NSCLC tissues compared to non-tumor lung tissues. Level of miR-30a was negatively correlated to tumor size, lymphatic metastasis, TNM stage, pathological grading, and histological classification.

results demonstrate that overexpression of miR-30a in lung adenocarcinoma A549 cells can inhibit cell migration and invasion, which is partially attributed to the decrease of EYA2 expression

plasma miRNA-30a measurement may be a novel and noninvasive method for non-small cell lung cancer preliminary screening and differential diagnosis.

our results demonstrated that miR-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM and have potential therapeutic value.

Study demonstrated that miR30a inhibits epithelial-mesenchymal transition (EMT) and invasion in highly invasive non-small cell lung cancer (NSCLC) cell lines via targeting PFN2 suggesting that miR30a with PFN2 may play an essential role in the development of NSCLC by modulating EMT and cell invasion.

miR-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of lung adenocarcinoma (LUAD). Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD

this study provides evidence for the existence of a p53/miR-30a-5p/SOX4 feedback loop, which likely plays a key role in the regulation of proliferation, apoptosis, and migration in non-small-cell lung cancer, highlighting a new therapeutic target.

LncRNA DLEU2 accelerates the tumorigenesis and invasion of non-small cell lung cancer by sponging miR-30a-5p.

miR30a3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2.

MiRNA-30 Play an Important Role in Non-Small Cell lung cancer (NSCLC).

miR-30a-5p Inhibits Proliferation and Migration of lung Squamous Cell Carcinoma Cells by Targeting FOXD1.