miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression

The miR-29 family (miR-29a, -29b, and -29c) suppresses the Wnt signaling pathway through demethylation of WIF-1 in non-small-cell lung cancer.

miR-29c and miR-429, but not miR-93, may have a role in early stage non-small lung cancer

miR-29c overexpression could abrogate the tumor progression and inhibit the Sp1/TGF-beta expressions in vivo, indicating that miR-29c could be a tumor suppressor and repress the Sp1/TGF-beta axis-induced EMT in lung cancer.

Results show that MiR-29c expression downregulation was significantly associated with unfavorable prognosis in IIIA-N2 lung adenocarcinoma (LAD). These data provide evidence that miR-29c plays a tumor suppressive role in LAD and its function is mainly mediated by its target-VEGFA.

low miR-29c levels correlated with shorter relapse-free survival of non-small cell lung carcinoma patients treated with radiotherapy. these results indicate a new role of miR-29c in radioresistance, highlighting their potential as a novel biomarker for outcomes of radiotherapy in lung cancer.