these data support the involvement of miR-22, miR-24, and miR-34a in advanced non-small cell lung cancer

MiR-22 over-expression attenuated lung cancer cell EMT and invasion via targeted inhibiting Snail.

Gain and loss-of-function studies were performed to verify whether DGCR5 exerts its biological functions through regulating hsa-mir-22-3p in vitro. Overexpression of DGCR5 was able to reverse the tumor inhibitory effect of hsa-mir-22-3p mimics. Furthermore, in vivo tests tumor xenografts were established to detect the function of DGCR5 in lung adenocarcinoma tumorigenesis.

miR-22 enhances the radiosensitivity of small-cell lung cancer by targeting the WRNIP1.

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) negatively correlates with microRNA (miR)-22 in HCC tissues and cell lines. Snail family transcriptional repressor 1 (SNAI1) is a direct target of miR-22 and that MALAT1 modulates SNAI1 expression by acting as a competing endogenous RNA for miR-22. MALAT1 facilitates the enrichment of enhancer of zeste homolog 2 (EZH2) at the promoter region of miR-22.

Neuroepithelial Cell Transforming Gene 1 Acts as an Oncogene and Is Mediated by miR-22 in Human Non-Small-Cell lung cancer.

LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis.