Mir-21 expression in the sputum specimens was significantly higher in non-small cell lung cancer patients than cancer-free individuals

These results suggest that aberrantly increased expression of miR-21, which is enhanced further by the activated EGFR signaling pathway, plays a significant role in lung carcinogenesis in never-smokers, as well as in smokers.

tumor suppressor phosphatase and tensin homolog PTEN is negatively regulated by miR-21 at post-transcriptional level via binding to 3'-untranslated region (UTR) of PTEN mRNA in non-small cell lung cancer cells.

data thus indicating the potential of miR-21, miR-143 and miR-181a as a novel diagnostic or prognostic biomarker for non small cell lung cancer.

increased miR-21 expression is associated with disease progression and survival in stage I lung cancer

High expression of serum miR-21 is associated with lung cancer.

miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway, MAPK signaling pathway, Wnt signaling pathway, cell cycle, PPAR signaling pathway, apoptosis pathway and other pathways

Suppression of tumor suppressor PDCD4 expression may be one of the important regulatory pathways of miR-21-mediated cell proliferation and decrease of apoptosis in non-small cell lung cancer.

our results suggest that miR-21, miR-205, miR-30d, and miR-24 may serve as potential novel non-invasive biomarkers for diagnosis of lung cancer

MiR-21 expression was inversely correlated with hMSH2 expression in human lung cancer cell lines.

miR-21 expression was associated with lymph node status and histological type in lung cancer.

The expression level of miR-21 in carcinoid tumors with lymph node metastasis was significantly higher than in carcinoid lung tumors without lymph node metastasis.

The tumorigenic role of miR-21 in non-small cell lung cancer development through modulation of the PTEN signaling pathway.

High miR-21 expression is associated with lung cancer.

miRNA-21 may be considered as a potential novel target for future development of specific therapeutic interventions in non-small cell lung cancer

Data indicate that the pattern of B cell translocation gene 2 (BTG2) protein expression was exactly the opposite of miRNA-21 expression in lung cancer cells.

The relative expressions of miR-205-5p, miR-205-3p, and miR-21-3p in tissues and serum among non-small cell lung carcinoma (NSCLC) patients, were assessed.

growth conditions especially expected in more malignant tumors result in microRNA-21 upregulation explaining the observed increase in higher staged lung cancer tissue, but not in lung cancer-derived cells.

High Serum microRNA-21 is associated with lung carcinoma.

The meta-analysis indicates that a single miR-21 may not be sufficient to identify lung cancer and that more miRNAs should be used to detect lung carcinoma.

these findings demonstrate that miR-21 suppression enhances the sensitivity of lung cancer cells to cisplatin (DDP) in vitro and in vivo.

Results show that up-regulation of miR-21 and down-regulation of Pten in patients with non-small cell lung cancer negatively correlate with shorter disease-free survival and poor sensitivity to treatment with tyrosine kinase inhibitors.

MiR-21 is critically essential for PHF8 function in human lung cancer cells.

this study demonstrated that miR-21 silencing reversed lung cancer cell MDR by modulation of MDR-related gene expression and inhibition of the AKT signaling pathway.

Nickel accumulation in lung tissues is associated with EGFR mutations, miR-21 expression, and a poor outcome in lung cancer never-smoking patients.

STAT3 and miR-21 are cooperative regulators of stemness, migration and tumor initiation in lung-derived brain metastasis

Up-Regulation of miR-21 expression is associated with Non-Small Cell lung cancer.

Results show that serum miR21 could serve as an important marker for auxiliary diagnosis of early non-small cell lung cancer (NSCLC), while joint detection of serums miR21 and CYFRA21-1 levels could improve diagnostic efficiency.

Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFbeta receptor signaling mediated non-small cell lung cancer cell invasion.

essential role of TLR4/ROS/miR-21 pathway in LPS-induced outgrowth of primary human lung cancer

Findings indicate that miR-21 and miR-155 promote the development of non-small cell lung carcinoma (NSCLC) in part by downregulating three tumor suppressor genes suppressor of cytokine signaling 1 protein (SOCS1), SOCS6, and PTEN.

The sequencing results showed that only several of miRNAs were differential, while the qRT-PCR further validated that most of them did not have the consistent differences. However, the levels of two upregulated miRNAs (miR-181b-5p and miR-21-5p) in lung cancer were significantly higher in exosomes than plasma

in this review, we focus on two microRNAs centrally involved in lung cancer progression. MicroRNA-21 promotes and microRNA-34 inhibits cancer progression. We elucidate here involved pathways and imbed these antagonistic microRNAs in a network of interactions, stressing their cancer microRNA biology, followed by experimental and bioinformatics analysis of such microRNAs and their targets

Results show that microRNA-21 expression is increased in non-small cell lung cancer (NSCLC) tissue and independently associated with poor survival in NSCLC patients.

Plasma miR-339-5p or miR-21 could serve as a potential biomarker for diagnosis of lung adenocarcinoma

Our experiment also verified the target relationship between miR-21 and HBP1. MiR-21 may affect migration and invasion ability of drug-resistant lung adenocarcinoma cells by targeting HBP1, therefore modulating EMT.

higher miR-21 levels were associated with a worse overall survival in lung adenocarcinoma patients.

Thus, miR-21 expression in lung fibroblasts may trigger fibroblast trans-differentiation into cancer-associated fibroblasts, supporting cancer progression in lung adenocarcinoma.

Elevated miR-21 is associated with poor prognosis in non-small cell lung cancer

High Circulatory miRNA-21 expression is associated with lung cancer.

MiR-21 suppressed the Hippo signaling pathway and promoted the progression of lung adenocarcinoma through targeting KIBRA.

miR-19 and miR-21 are highly expressed in peripheral blood of patients with undifferentiated lung cancer

Results found that miR-21 was upregulated in non-small cell lung cancer (NSCLC) tissues. Its expression is directly regulated by TP73-AS1 to promote NSCLC cell migration and invasion.

Findings show that miRNA-21 (miR-21) is a potential target for the development of treatment for non-Small Cell lung cancer (NSCLC) forms of lung cancer.

Authors suggest that SET/TAF-Ialpha might be a tumor suppressing factor regulated by miR-21-5p in lung adenocarcinoma.

hsa-miR21 and TGF-beta1 are involved in autocrine and paracrine circuits that regulate the epithelial-mesenchymal transition status of lung cancer cells.

lncRNA PLAC2 down-regulated miR-21 in non-small cell lung cancer and inhibited cancer cell migration and invasion.

miRNA-21 may play a significant role in cell cycle, cell proliferation, and cell division related to biological process in lung cancer partly via MCM10 and CDCA8.

Study found that miRNA-21 expression level is increased through a mechanism involving angiotensin II in non-small-cell lung adenocarcinoma.

MiR-21, EGFR and PTEN in non-small cell lung cancer: an in situ hybridisation and immunohistochemistry study.

Clinicopathological significance of microRNA-21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal transition.

Propofol suppresses the progression of nonsmall cell lung cancer via downregulation of the miR215p/MAPK10 axis.

3'-Terminal 2'-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2.

miR-21-5p promotes lung adenocarcinoma cell proliferation, migration and invasion via targeting WWC2.

Long noncoding RNA MEG3 inhibits cell migration and invasion of nonsmall cell lung cancer cells by regulating the miR215p/PTEN axis.

Circulating miR-21-5p and miR-126-3p: diagnostic, prognostic value, and multivariate analysis in non-small-cell lung cancer.