our study suggests that miRNA 17 family (including miR-17, 20a, 20b) can act as TGFbetaR2 suppressor for reversing cisplatin-resistant and suppressing metastasis in non small cell lung cancer.

Mir-20a controls expression of the iron exporter ferroportin (FPN1) by binding to highly conserved target sites in its 3'-untranslated region. expression of miR-20a is inversely correlated to FPN1 in lung cancer.

Patients with non-small cell lung cancer (NSCLC) and high plasma expression levels of miR-18a, miR-20a, and miR-92a as well as lymphatic node metastasis had a shorter overall survival than patients with low expression levels of these miRNAs. Thus, the circulating miR-18a, miR-20a, and miR-92a levels may serve as novel and promising prognostic biomarkers in patients with NSCLC.

MiRNA-20a-5p accelerates the proliferation and invasion of non-small cell lung cancer by targeting and downregulating KLF9.