MicroRNA-19a functions as an oncogenic microRNA in non-small cell lung cancer by targeting the suppressor of cytokine signaling 1 and mediating STAT3 activation

MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition.

Data suggest that expression of two microRNAs (MIRN19b-3p; MIRN29b-3p) by peripheral blood mononuclear cells may serve as biomarkers for early detection/diagnosis of non-small-cell lung carcinoma (with 72.62% sensitivity and 82.61% specificity).

findings have provided the first clues regarding the roles of miR-19a/b, which appear to function as oncomirs in lung cancer by downregulating MTUS1.

Oncogenic miR-19a and miR-19b were up-regulated in lung cancer stem cells which modulated cancer cells activity. miR-19 activated Wnt/beta-catenin pathway via directly targeting Glycogen Synthase Kinase 3 beta. Sulforaphane suppressed lung cancer stem cells through down-regulating miR-19 and inhibiting Wnt/beta-catenin pathway activation.

LncRNA FAS-AS1 inhibits the progression of non-small cell lung cancer through regulating miR-19a-5p.