study found that miR-196a2 rs11614913 variant homozygote CC was associated with approximately 25% significantly increased risk of lung cancer compared with their wild-type homozygote TT and heterozygote TC

IT did not find any association between miR-196a2 genotype and risk of non-small cell lung carcinoma.

Association study was performed to reveal the relation between SNP and response rate or severe toxicity after platinum-based regimen in advanced nonsmall cell lung cancer patients.

The rs11614913 polymorphism is significant associated with the increased risk of lung cancer, especially in Asians.

This meta-analysis suggests that the miR-196a2 rs11614913 polymorphism may contribute to decreased susceptibility to cancer, especially including liver cancer and lung cancer. However, it may be a risk factor for cancer development in Asians.

MiR-196a2 gene rs11614913 polymorphism is associated with lung cancer risk.

The combined presence of miR-146a G>C and miR-196a2 polymorphisms showed increased risk for small-cell lung cancer as well as adenocarcinoma

Downregulation of microRNA-196a inhibits stem cell self-renewal ability and stemness in non-small-cell lung cancer through upregulating GPX3 expression.(105571)