overexpression of miRNA-148a significantly suppressed the migratory and invasive abilities of A549 and H1299 lung cancer cells.

Serum miR-148a, miR-148b, and miR-152 were significantly downregulated in NSCLC patients. The combination of four candidate miRNAs exhibited the highest predictive accuracy in non-small cell lung cancer screening compared

relative expression levels of miR-148/152 family (miR-148a, miR-148b, and miR-152) in serum of 36 non-small-cell lung carcinoma patients, 20 patients with benign pulmonary diseases, and 10 healthy individuals

The miR-148a expression suppressed NSCLC cell invasive and migratory abilities in vitro and suppressed cancer metastasis in vivo, while inhibition of miR-148a enhanced NSCLC cell invasion and lung metastasis formation in a mouse model.

MiRNA-148a inhibited cell migration and invasion through targeting Wnt1 and this might provide a new insight into the molecular mechanisms of lung cancer metastasis.

miR-148a-3p inhibits non-small-cell lung cancer cells proliferation and epithelial-mesenchymal transition by reducing the expression of SOS