CG genotype of miR-146a appeared associated to an increased risk for non-small cell lung carcinoma.

miR-146a inhibits cell growth and induces cell apoptosis in non-small cell lung cancer cells. miR-146a causes inhibition of EGFR and NF-kappaB signaling.

A common polymorphism in pre-microRNA-146a is associated with lung cancer risk in a Korean population

MiR-19b and miR-146a are potential biomarkers for the prediction of survival and response to chemotherapy in non-small cell lung cancer.

Decreased miR-146a expression contributes to the up-regulation and overexpression of COX-2 in lung cancer cells.

MiR-146a gene rs2910164 polymorphism is associated with lung cancer risk.

This meta-analysis demonstrates that Mir-146a and mir-149 SNP do not play a role in lung cancer risk.

These preliminary data suggest that serum miR-125a-5p, miR-145 and miR-146a may be useful noninvasive biomarkers for the clinical diagnosis of Non-small-cell lung cancer.

The combined presence of miR-146a G>C and miR-196a2 polymorphisms showed increased risk for small-cell lung cancer as well as adenocarcinoma

These data demonstrate for the first time that miR146a suppresses lung cancer progression by repressing IRS2 expression

these results demonstrated that miR-146a-5p could suppress the proliferation and cell cycle progression in non-small cell lung cancer cells by inhibiting the expression of CCND1 and CCND2

miR-146a rs2910164 polymorphism may influence susceptibility to lung cancer in Chinese nonsmoking females through targeting TRAF6.

Low miR146a expression is associated with drug resistance in non-small cell lung cancer.

MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma

CHOP was identified as a target of miR-146a, and increased miR-146a expression in lung cancer cells was suggested to be responsible for CHOP mRNA down-regulation. Animal models confirmed that abnormally expressed miR-146a in lung cancer cells does not affect growth, but rather alters chemotherapy sensitivity.

Study verified the target action association between TCSF and miR146a5p with high throughput data analysis and experimental results in nonsmall cell lung cancer (NSCLC). Protein level of TCSF in cancerous lung tissues was upregulated in NSCLC tissues. In vitro experiment in A549 cell line revealed that miR-146a-5p had a role in cell viability, proliferation and apoptosis by regulating the target gene TCSF.

miR-146-5p suppression inhibits cell viability, migration and invasion but promotes apoptosis in human lung cancer cell A549. Overexpression of miR-146-5p reduces the sensitivity of A549 and WI-38 cells to cisplatin. Claudin-12 is a direct target of miR-146-5p and is negatively regulated by miR-146-5p. miR-146-5p overexpression activates Wnt/beta-catenin and PI3K/AKT/MAPK signal pathways via downregulation of claudin-12.

miR-146a-5p displays the tumor suppressive role in non-small cell lung cancer cells.

Epidemiological evidence for associations between variants in microRNA or biosynthesis genes and lung cancer risk.

Upregulation of miR-146a by TNF in lung adenocarcinoma promotes Merlin protein inhibition and metastasis.

Association between miRNA-146a polymorphism and lung cancer susceptibility: A meta-analysis involving 6506 cases and 6576 controls.