Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

miR-140-3p expression level was lower in lung cancer tissues compared to adjacent normal lung cancer tissue. After miR-140-3p was upregulated in A549 or H1299 cells, cell proliferation, invasion and migration was notably attenuated.

High miR-140 expression is associated with non-small cell lung cancer.

miR-206 and miR-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3.

These findings indicated that XIST may regulate the tumor growth and metastasis via miR-140-dependent iASPP regulation. Taken together, our data indicated that XIST may be an oncogenic lncRNA that promotes the proliferation and metastasis of lung cancer through the regulation of miR-140 and could be regarded as a therapeutic target in human lung cancer.

The miR1405p/VEGFA axis inhibits the migration and invasion of nonsmall cell lung cancer cells via inactivation of pAKT signaling.

miR-140-3p inhibited squamous cell lung cancer cell proliferation and invasion in vitro and in vivo by targeting BRD9 expression.

MicroRNA-140's inhibition on the cell migration and invasion of non-small cell lung cancer by down-regulating Smad3 expression.

LncRNA HANR aggravates the progression of non-small cell lung cancer via mediating miRNA-140-5p.

miR-140-3p inhibits progression of non-small cell lung cancer by targeting Janus kinase 1.