Our results indicated that miR-139-5p acts as a tumor suppressor in non-small cell lung cancer partially via down-regulating IGF1R expression.

H3K27me3-mediated silencing of miR-139 enhances an invasive and metastatic phenotype of non-small-cell lung cancer.

Results demonstrated that miR139 plays a positive role in the regulation of mesenchymal stem cells (MSCs) osteogenic differentiation which is mediated by Notch1 and its signaling pathway. Also, the expression of serum miR139 from lung adenocarcinoma patients with lytic bone metastasis was significantly lower compared to the patients with metastasis at other sites.

Low miR139 expression is associated with lymph node metastasis in non-small cell lung cancer.

The long non-coding RNA MIAT/miR-139-5p/MMP2 axis regulates cell migration and invasion in non-small-cell lung cancer.

LINC00324 affects non-small cell lung cancer cell proliferation and invasion through regulation of the miR-139-5p/IGF1R axis.

miR1395p enhances cisplatin sensitivity in nonsmall cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein HoxB2.