The functional significance of miR-133a in cancer cell lines derived from lung squamous cell carcinoma (SCC) and the identification of miR-133a-regulated novel cancer networks in lung-SCC, are reported.

Reduced miR133a expression is associated with lung cancer.

the tumor suppressor role of miR-133a in lung cancer

Data indicate that coronin 1C protein (CORO1C) was a direct target of the microRNA miR-1/133a cluster in EBC-1 CORO1C was a direct target of the miR-1/133a cluster in lung-squamous cell carcinoma cell line EBC-1.

analysis of the correlation between miR-133a expression level and clinicopathologic features and its prognostic significance in non-small cell lung cancer (NSCLC); findings show miR-133a was down-regulated in NSCLC; decreased expression of miR-133a might be a potential unfavorable prognostic factor for patients with NSCLC

miR-133 involves in lung adenocarcinoma cell metastasis by targeting FLOT2

Study indicated that miR-133a might act as a tumor suppressor and be a valuable independent prognostic and diagnostic biomarker for non-small cell lung cancer (NSCLC), and NSCLC patients with high expression of miR-133 might have a better prognosis.[meta-analysis]