examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis

miR-125a-3p and miR-125a-5p play distinct roles in regulation of invasive and metastatic capabilities of lung cancer cells.

HSA-miR-125a-5p induces apoptosis via a p53-dependent pathway in human lung cancer cells.

These results provide new insights into the role of the miR-125a family in lung cancer.

hsa-miR-125a-3p induces apoptosis not only via the p53 pathway in human lung cancer cells.

miR125a loss may have a role in k-ras dependent lung carcinogenesis

These preliminary data suggest that serum miR-125a-5p, miR-145 and miR-146a may be useful noninvasive biomarkers for the clinical diagnosis of Non-small-cell lung cancer.

Data show that proto-oncogene protein HER-2 is directly regulated by microRNAs miR-125a and miR-125b in small cell lung cancer (SCLC).

Overexpression of microRNA125a3p effectively inhibits the cell growth and invasion of lung cancer cells by regulating the mouse double minute 2 homolog/p53 signaling pathway

Zbtb7a knockdown by siRNA suppressed cell proliferation and induced G1 cell cycle arrest and apoptosis in lung cancer cells. Furthermore, miR-125a expression showed a negative correlation with Zbtb7a expression in non-small cell lung cancer tissues.

Taken together, mir-125a-5p inhibited the proliferation and invasion of lung cancer cells and facilitated lung cancer cell apoptosis through suppressing STAT3. Enhancing the expression of miR-125a-5p is expected to benefit the therapy for the patients with lung cancer.

MiR-125a-5p may serve as a therapeutic agent for lung adenocarcinoma through its major target, NEDD9.

Study demonstrated that miR-23b cluster and miR-125a-5p are downregulated by increased expression of PDGFR-alpha or PDGFR-beta in non-small cell lung cancer (NSCLC) cells. Mechanistically, the expression of these microRNAs is positively regulated by p53 and negatively modulated by NF-kB p65.

HuR facilitated lung cancer stemness dependent on CDK3 expression. miR-873 or miR-125a-3p level was negatively correlated with HuR and CDK3 expression levels in lung cancer tissues. HuR facilitates lung cancer stemness via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.

The miR125a5p/TMPRSS4/NFkappaB axis may thus provide novel insight into the pathogenic mechanisms of lung adenocarcinoma and may be used in the development of novel treatment strategies for lung adenocarcinoma .

The rs12976445 SNP in miR-125a is associated with the risk of pneumonitis after in lung cancer patients undergoing the radiotherapy by regulating the expression of miR-125a and TGFB1.

Study found that rs8111742 upstream of miR-125a was associated with the prognosis and survival of Chinese non-small cell lung cancer (NSCLC) patients.

MicroRNA-125a attenuates the chemoresistance against ubenimex in non-small cell lung carcinoma via targeting the aminopeptidase N signaling pathway.

Our results indicated that the miR-125a level varies in non-small cell lung carcinoma cell lines with different radiosensitivities. We demonstrated that miR-125a-5p upregulated SIRT7 and further upregulated apoptosis in lung cancer cells to increase their radiosensitivity.