Links to all GeneRIF Items | 4015 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 17616686 (LOX) | BCL2 repression by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells |
| 20956321 (LOX) | LKB1 loss of function promotes lung cancer malignancy through remodeling of extracellular matrix microenvironment, and identify LOX as a potential target for disease treatment in lung cancer patients. |
| 22438909 (LOX) | Blimp1 is a mediator of Ras/Raf/AP-1 signaling that promotes cell migration, and is repressed by LOX-PP in lung cancer. |
| 22948781 (LOX) | LOX 473 G/A polymorphism is associated with increased risk of nonsmall cell lung cancer. |
| 25337249 (LOX) | LOX may play a role in the metastasis of non-small cell lung cancer by promoting MMP2/MMP9 expression. LOX expression is an independent prognostic factor for survival in NSCLC. |
| 27367711 (LOX) | LOX G473A polymorphism apparently elevated human sensitivity to cigarette smoking carcinogens for eliciting cancers in the lung and colon only. Thus, LOX G473A polymorphism positively correlates with carcinogenesis and it may be used as an ideal intrinsic biomarker for prediction or diagnosis of carcinogenesis in humans. |
| 29766649 (LOX) | LOX nuclear localization was significantly associated with poor survival in patients with Colorectal cancer (CRC). Nuclear LOX expression was correlated with synchronous or postoperative lung/hepatic metastasis. LOX may prove to be a potential target gene of YAP and TEAD4. |
| 21690299 (Lox) | LOX-PP is shown to negatively regulate pro-oncogenic beta-catenin signaling in lung cancer cells. |