RhoA signaling has a role in lung cancer

PRL-3 up-regulates pERK and Rho expression and activity in lung cancer

RHOA overexpression correlates with progression of non-small cell lung cancer.

co-expression of Delta-catenin and RhoA was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis in non-small cell lung cancer

The knockdown of RhoA prevents proliferation and metastasis in SPCA1 lung cancer cells.

ACTB, CDKN1B, GAPDH, GRB2, RHOA and SDCBP are potent reference genes in neuroendocrine tumors of the lung.

MDA-9 upregulated active levels of known modulators of epithelial mesenchymal transformation, the small GTPases RhoA and Cdc42, via TGFbeta1, promoting lung metastasis of breast cancer cells.

Study report that galectin3 expression is upregulated in nonsmall cell lung cancer cells under hypoxia and that it contributes to tumor cell migration and invasion. Cell motility is upregulated by the function of activated RhoA, which is induced by high levels of cytoplasmic galectin3.

Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-kappaB activity.

LncNORAD interference inhibits tumor growth and lung cancer cell proliferation, invasion and migration by down-regulating CXCR4 to suppress RhoA/ROCK signaling pathway.

Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line.

RHOA-FAK is a required signaling axis for the maintenance of kRAS-driven lung adenocarcinomas

beta-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA/Rock signaling

Findings suggest the mechanisms by which tumor protein p53 (p53) operates to enhance vascular endothelium barrier function by mediating the opposing actions of Rac family small GTPase 1 (Rac1) and ras homolog family member A (RhoA) in pulmonary tissues.