overexpression of the c-kit protein is associated with large cell neuroendocrine carcinoma of the lung

overexpression of c-KIT is associated with extensive-stage small-cell lung carcinoma

CD117 immunoreactivity identifies a peculiar subset of stage I adenocarcinoma and squamous cell carcinoma of the lung with highly proliferative tumors and may have prognostic relevance in adenocarcinoma patients.

neither c-kit nor its mutational status have a role in progression of small cell lung cancer

Overexpression and phosphorylatiom of kit receptor is associated with small cell lung cancer

Our findings reveal an important role for the SCF-c-kit signaling axis in self-renewal and proliferation of lung cancer stem cells

The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma.

cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer

Kit mutations were absent in small cell lung carcinoma and protein expression did not provide prognostic information.

Overexpression of CD117 in CD117(high) non small cell lung carcinoma supports exploring KIT as a therapeutic target in this subset of patients.

useful in distinguishing thymic carcinoma from poorly differentiated lung carcinoma

Our finding reveals that somatic mutation of KIT is rare in small cell lung cancer patients from the northeast China

interference of miR-137 expression may attenuate drug resistant of small lung cancer cells, partially through KIT expression regulation

Mast cell exosomes promote lung adenocarcinoma cell proliferation - role of KIT signaling

High c-kit expression is associated with high-grade neuroendocrine carcinomas of the lung

These findings identify functional cross-talk between KIT and DNMT1 in the development of drug resistance, implying the reciprocal targeting of protein kinases and DNA methyltransferases as an essential strategy for durable responses in lung cancer.

activation of KIT by a gain-of-function, somatic mutation is a novel mechanism of resistance to crizotinib in ROS1 rearranged non-small cell lung cancer

High c-kit expression is associated with small cell lung cancer.

KIT and DNMT1 co-expression promotes, whereas dual inactivation of them suppresses, lung cancer cell proliferation and metastatic growth in vitro and in vivo, in a synergistic manner.

CD117 expression might be a potential marker for predicting poor prognosis, faster tumour growth, and early lymph node metastasis in non-small cell lung carcinoma [meta-analysis]