OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin.

The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients

beta3-integrin has an essential effect on tumor cell proliferation and progression, and may be a potential therapeutic target for the prevention of skeletal metastases of lung cancer.

Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha.

Overexpression of osteopontin, alphavbeta3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer.

ITGB3 and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells.

Studied expression heterogeneity of ITGB3 and BCL-2 in lung adenocarcinoma tissue and adenocarcinoma cell line.

expression of the alphavbeta 3 integrin subunit seems to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases

ITGbeta3 and CD44 expression levels determine whether OPN-a inhibits or enhances growth in lung cancer cells.

Our findings suggest that high integrin b3 expression in ALK-rearranged non-small cell lung cancer (NSCLC) is associated with tumor progression and a worse prognosis. This finding demonstrates the prognostic value of integrin b3 and provides a rationale for combination treatment with ALK and integrin b3 inhibitors in patients with ALK-rearranged NSCLC.

Downregulation of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer.