Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines.

Ionizing radiation strongly induced the expression of functional beta1-integrin and ILK in the two lung cancer cell lines, A549 and SKMES1.

Data suggest that the early arrest of tumor cells in the pulmonary vasculature through interaction of alpha3beta1 integrin with laminin-5 in exposed basement membrane provides a basis for cell arrest during pulmonary metastasis.

Calu-1 lung cancer cells use primarily a beta1-integrin-mediated intracellular tyrosine phosphorylation phenomenon as the key regulatory mechanism for its binding advantage to Coll IV matrix.

uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells.

upregulated expression in lung adenocarcinoma cells following bacterial infection

The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients

results show beta1-integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy.

integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression

osteopontin, LAMB3 and ITGB1 played important roles in the occurrence and metastasis of lung cancer, thus provided important clues to understanding the molecular mechanism of metastasis.

The data suggest that integrin beta1 is a potential biomarker for lymph node metastasis and prognosis of lung adenocarcinoma and integrin beta1 upregulation may play an important role in the pathogenesis of lung adenocarcinoma.

miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression

Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy.

Study demonstrates that MARVELD1-mediated balance of integrin beta1 and beta4 regulates cell surface ultrastructure and epithelial-mesenchymal transition phenotype of non-small cell lung cancer (NSCLC).

High ITGB1 expression is associated with lung metastasis in ovarian cancer.

High expression of ITGB1 is associated with migration and invasion of nonsmall cell lung cancer.

VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a beta1 integrin/VEGFR autocrine loop.

In vivo experiments showed that miR3653 overexpression inhibited the subcutaneous and the lung metastasis of HCCLM3 cells in nude mice. Mechanistically, integrinbeta1 (ITGB1) was identified to be the downstream target of miR3653 in hepatocellular carcinoma.

work identifies the essential role of CUL5- and SOCS3-mediated integrin beta1 turnover in controlling small-cell lung cancer metastasis, which might have therapeutic implications.

High expression of UBB, RAC1, and ITGB1 Predicts Worse Prognosis among Nonsmoking Patients with lung Adenocarcinoma through Bioinformatics Analysis.

both Kras and integrin alpha1beta1 cooperate to drive the growth of non-small cell lung cancer in vivo

These results demonstrate the critical role of integrin beta(1)-FAK signaling axis in controlling the initial proliferation of micrometastatic cancer cells disseminated in the lungs.