upregulated expression in lung adenocarcinoma cells following bacterial infection

Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha.

Overexpression of osteopontin, alphavbeta3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer.

The level of OPN expression in lung adenocarcinoma was associated with decreased apoptotic activity of tumor cells, and correlated with alphav integrin expression, particularly in low stage tumors.

expression of alphav integrin subunits seem to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases.

Integrin alphav promotes the proliferation of the human lung cancer cell line A549 by activating the ERK 1/2 signaling pathway

findings establish that Api6/AIM/SPalpha/CD5L promotes lung tumorigenesis by blocking a mechanism of epithelial apoptosis that would normally support immunosurveillance