cancer cells in the lungs and bone metastases markedly produced IL-18

This is the first report to investigate the association between IL-18 polymorphism and lung cancer. Our results suggest that IL-18 polymorphism contributes to the lung cancer risk, particularly among squamous carcinoma patients.

VEGF and IL-18 ratios are different in induced sputum of patients with different types of lung cancer (NSCLC and SCLC), indicating differences in angiogenesis mechanisms and/or immunological response in these two major histological types of lung cancer

Report IL-18 plus GM-CSF modified tumor cell vaccine can induce significant antitumor effects in Lewis lung carcinoma.

Using MDR and RF, the overall best classifier of lung cancer status were SNPs rs1799732 (DRD2), rs5744256 (IL-18), rs2306022 (ITGA11) with training accuracy of 0.6592 and a testing accuracy of 0.6572 and a cross-validation consistency of 10/10 with permutation testing P<0.0001

Results provide evidence for IL18-607C/A variation related to the pathogenesis of non-small cell lung cancer in the Chinese population studied.

The potential influences of IL-10, IL-18 and IL-12 polymorphisms on non-small cell lung cancer (NSCLC) risk were explored in this study.