Snail upregulation plays a role in non-small cell lung carcinoma by promoting tumor progression mediated by CXCR2 ligands

CXCR2 axis gene expression profiles in human NSCLC cell lines and lung adenocarcinomas defined a cluster driven by CXCL5 and associated with smoking, poor prognosis, and RAS pathway activation.

the CXCR-2 +1208 C>T polymorphism is an independent prognostic marker in patients with squamous cell lung carcinoma and is associated with aggressive tumor biology and shorter disease-free survival

miR141-CXCL1-CXCR2 signaling-induced Treg recruitment regulates metastases and survival of non-small cell lung cancer.

3'UTR SNP modulates CXCR2 expression, signaling, and susceptibility to lung cancer

G31P blockage of CXCR1 and CXCR2 can inhibit human lung cancer cell growth and metastasis

C-X-C chemokine receptor 2 correlates with unfavorable prognosis and facilitates malignant cell activities via activating JAK2/STAT3 pathway in non-small cell lung cancer.

lung adenocarcinoma-related TNF-alpha-dependent inflammation upregulates MHC-II on alveolar type II cells through CXCR-2 to contribute to Treg expansion.

CXCR2 mediates the angiogenic activity of Glu-Leu-Arg motif-positive CXC chemokines; tumor growth in Lewis lung carcinomas is reduced and lung metastases are decreased in the CXCR2-/- knockout mice model.

lung cancer promotion by inflammation is partly mediated by activation of the IL-8/CXCR2 pathway and subsequent recruitment of neutrophils and release of neutrophil elastase.

Only band III granulocyte myeloid-derived suppressor cells (G-MDSCs) display significant expansion in B16 melanoma, Lewis lung carcinoma, or MC38 colon carcinoma. The expanded G-MDSCs also show increased CXCR2 expression.